Abstract
Summary
Conversion of mevalonic acid to non-saponifiable material by rat liver homoge-nates under conditions where conversion is a function of ATP level existing at time of mevalonic acid addition was inhibited markedly by preincubation with protamine or polylysine. Inhibition was less or absent following preincubation with trypsinized protamine, bovine serum albumin or a number of small molecular weight bases. The results are interpreted as indicating that a combination of high molecular weight and strong basicity are essential for inactivation of a polyanion previously shown to be essential for maintenance of ATP levels in liver homogenates.
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