Abstract
Summary
Mouse leukemia (L1210) was grown successfully when introduced by intracerebral route. Brain tissue was rapidly infiltrated and the disease became systemic 2-3 days following I.C. inoculation. Deaths occurred somewhat sooner than when the disease was inoculated S.C. Administration of antifolic agents (amethopterin and 3′,5′-dichloroamethopterin) increased survival time.
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