Abstract
Summary
INH is stable for several weeks in aqueous and buffered solution at pH values below 8 and at low temperature. It is unstable in human and rabbit plasma whether added to pure plasma or present after oral or parenteral administration. Instability is enhanced by increased temperature, but is quite marked at refrigerator temperature. The presence of a factor in blood causes changes in chemical state of INH so that it no longer reacts with reagent used in the assay method.
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