Interaction of Chlorpromazine with Strandin. ∗

Abstract

Summary

1) Chlorpromazine and stelazine interact with heparin and CSA to form products of visible turbidity. This turbidity is reduced by strandin, and reappears on readdition of phenothiazine. 2) Chlorpromazine reduces turbidity of the strandin-lysozyme interaction product, turbidity of which may be regenerated by subsequent addition of strandin. It also destroys metachromasy of the toluidine blue O-strandin system. 3) Equilibrium dialysis of chlorpromazine solutions and chlorpromazine-strandin solutions indicates good retention of chlorpromazine in the system containing strandin. 4) Strandin alters U.V. absorption spectrum of chlorpromazine and, more markedly, that of stelazine. 5) Ultracentrifuge studies indicate presence of slow moving peak in the strandin-chlorpromazine system, which may represent strandinchlorpromazine interaction product.