Abstract
Conclusions
Technical DDD fed to dogs in 200 mg/kg doses once daily for 3 days resulted in histologically normal adrenal glands which responded to ACTH with the expected increase in blood flow, but demonstrated a low resting secretion rate of 17-hydroxycorticosteroids, which did not increase after administration of ACTH. Dogs fed a similar 3 doses and allowed to continue normal diet for 18 days showed adrenals with definite changes in the cortex which did respond to ACTH with the expected increase of steroid secretion but showed usual increase in blood flow. These data are interpreted to mean that the vasodilating factor of commercial ACTH is separate from steroid formation and/or releasing factor(s) and possibly the vasodilating factor may act on medullary or extracapsular vasculature. Capacity of the cortical parenchymal cells to form and/or release 17-hydroxycorticosteroids, as influenced by DDD, does not parallel histological changes observed in standard hematoxylin and eosin preparations.
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