Histamine in Intestinal Lymph of White Rat During Anaphylactic Shock. ∗

Abstract

Conclusions

1) Bovine γ globulin is a satisfactory antigen for sensitizing rats when given intraperitoneally simultaneously with Bordetella pertussis vaccine. Intestinal lymph of animals so sensitized contains increased amount of histamine when collected 6 minutes after intravenous injection of shocking dose. The amount is roughly proportional to degree of shock. Rate of flow of lymph increases 8 to 25 times during the 12 minutes immediately after administration of shocking dose. 2) Lymph from mesenteric lymphatic system contains 0 to 0.02 μg histamine/ml, an amount similar to that in plasma. 3) A limited number of studies suggest that rats treated with polymyxin B sulfate and distilled water before shock were only partly depleted of histamine.