Abstract
Summary
A comparison was made of time and incidence of death between lethally irradiated mice injected with non-immune rat bone marrow and those injected with marrow from rats pre-immunized against recipient strain of mice. Statistical analysis of data showed no significant differences between the 2 groups of animals. Similarly, a lack of significant difference was observed with marrow-treated mice given a supplementary injection of moderate amounts of either non-immune or pre-immunized rat spleen cells. The failure of sufficient numbers of immunologically active cells to colonize and proliferate is discussed as the most probable interpretation of the results.
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