Abstract
Summary
Chronic epilepsy has been produced in the mouse by cerebral implantation of various powdered metals, notably cobalt and nickel. In addition to spontaneous focal and generalized seizures, epileptic status was evaluated by response to challenge injections of Metrazol and semicarbazide, as well as to electroshock.
Addendum. Cobalt implanted intracerebrally, in the manner described for mice, has recently proved highly epileptogenic in the rat as evidenced by lowered convulsive threshold to Metrazol.
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