Abstract
Summary
A total number of 282 single sputum specimens from patients with acute respiratory disease were stained by Papanicolaou technic and examined for presence of certain abnormalities, known as ciliocytophthoria (CCP), in exfoliated ciliated epithelial cells. Fifty-nine % yielded positive results, 30% were negative, and 11% inconclusive. During this period complement fixation (CF) tests carried out on paired acute and convalescent sera from 578 patients demonstrated high incidence (77%) of adenovirus infection. The direct association of CCP with adenovirus infection was established by study of patients from whom sputum as well as serum specimens were obtained. Significant adenovirus antibody rises occurred in 48 (80%) of 60 individuals whose sputum specimens were positive for CCP.
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