Abstract
Summary
Adult female Swiss Webster mice kept at temperature of 78°F were observed to eat 1.3g/10 g body weight/day of Purina Lab. Chow. Their daily L-thyroxine secretion rate (TSR) was 1.38 ± .173μg/100 g body weight. Mice fed 3/4 ration for 16 days showed TSR of 0.93 μg/100 g/day, a significant reduction of 33%, yet no loss in body weight occured. On 1/2 ration the TSR was reduced to 0.80 μg/100 g/day or 41% associated with a 17.3% reduction in body weight. These data suggest that pituitary-thyroid axis is sensitive to slight reduced energy intake by reduction in TSR sufficient to maintain body weight.
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