Abstract
Summary
Overt signs of CNS depression were elicited only in response to toxic doses of amphenidone. Selective central depressant activity was revealed by 1) blockade of stimulant effects of LSD; 2) anticonvulsant activity against electrically and chemically induced seizures; and 3) analgesic activity. In the anesthetized dog and cat, blood pressure and respiration were affected only by lethal doses of the drug. Large doses of amphenidone did not alter blood pressure responses to acetylcholine, epinephrine, norepinephrine or serotonin. Contractions of nictitating membrane in response to electrical or chemical stimulation were not altered by amphenidone. Normal functioning of isolated heart was not affected by addition of massive doses of the drug to perfusion fluid, nor, in the intact dog, was the ECG (lead 2) changed.
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