Effect of Corticotropin and Growth Hormone on Allantoin Synthesis and Excretion in the Dog. ∗

Abstract

Summary

1. Growth hormone increased amount of ammonium citrate-N¹⁵ utilized for allantoin synthesis in dogs. Corticotropin did not have this effect. Neither hormone increased incorporation of N¹⁵ from glycine into allantoin. 2. Corticotropin increased output of urinary allantoin in dogs, without markedly reducing the specific enrichment with N¹⁵ in this excretory product. One possible interpretation of this finding is increased synthesis of allantoin, without qualitative changes in its origin.