Abstract
Summary
External balance studies for magnesium and isotopic determinations of exchangeable magnesium content of body were made in 8 adult male rabbits before and after 8 daily injections of pyridoxine (100 mg), and in another group of 8 rabbits before and after 6 daily injections of desoxypyridoxine, 40 mg/kg. Except for increase in mean body weight in the group receiving pyridoxine, no significant changes were observed. In 8 animals given 2 intravenous injections of pyridoxine (100 mg) 24 hours apart, relative tissue activity of Mg28 was increased in appendix and heart. In 15 rabbits given desoxypyridoxine, 40 mg/kg, daily for 7 days, there was a significant decrease in relative activity of kidney, lung, and bone, and a significant increase in serum magnesium concentration. The results suggest that excess or deficiency of pyridoxine alters rate of uptake of Mg28 by various tissues.
Mg28 was supplied by Brookhaven National Lab. on allocation from U. S. Atomic Energy Comm.
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