Erythropoietic Recovery Measured by Fe 59 Uptake in Irradiated Mice Protected with Bone Marrow. ∗

Abstract

Summary

24 hour uptake of Fe₅₉ was used as quick measure of erythropoiesis in Swiss male mice. In normal nonirradiated mice, iron uptake is not affected by intravenous injection of isologous, homologous and heterologous bone marrow cells except for inocula greater than 40 × 10⁶ cells. Injection of these cell types after 900 R whole body x-radiation increases Fe₅₉ uptake rates in the order: heterologous, homologous, isologous. Protection against lethal radiation effect as measured by survival and Fe₅₉ uptake depended on genetic relationship between bone marrow donor and recipient.