Abstract
Summary
In confirmation of biochemical data for whole brain, injection of thiosemicarbazide produced convulsive seizures in rats concomitantly with decreases in levels of γ-aminobutyric acid in 9 areas of the brain. However, rats injected with both hydroxylamine and thiosemicarbazide had convulsive seizures when levels of γ-aminobutyric acid were either elevated or normal in different areas of brain. Seizures produced by administration of thiosemicarbazide are not related to a generally decreased level of γ-aminobutyric acid in the brain.
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