Role of Local Trauma in Production of Cutaneous Calcinosis by Dihydrotachysterol. ∗

Abstract

Summary

In rats, a cutaneous calcinosis with sclerosis, not unlike that seen in certain types of clinical scleroderma, can be produced at will in predetermined regions of the skin. This is best accomplished if, at a critical time of systemic dihydrotachysterol overdosage, the selected cutaneous area is lightly traumatized by epilation.