Abstract
Summary
1) After oral and intravenous administration of Penicillin G and other known penicillins to mice, and oral administration to rats, dogs, rabbits, and man, 6-APA was detected in urine. After oral administration of penicillin to guinea pigs 6-APA was not detected in urine. 2) Tissue macerates of these animals failed to convert Penicillin G to 6-APA. 3) Probably 6-APA in urine is the result of microbial hydrolytic conversion of penicillin in the intestine and subsequent absorption and excretion.
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