Abstract
Summary
(1) Several phenolic acid metabolites of flavonoids and compounds related to these metabolites were tested for thymolytic action by feeding in the diet to young normal rats. (2) Catecholic acids 3,4-dihydroxyphenylacetic, protocatechuic and caffeic. accelerated thymus involution. Several other phenolic acids did not. (3) 3,4-Dihydroxyphenylacetic acid did not accelerate thymus involution in either hypophysectomized or adrenalectomized rats. (4) Whether the action of flavonoids on thymus involution is due to intact flavonoids or their metabolites is discussed.
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