Abstract
Summary
Distribution and concentration of Zn65 in whole blood, plasma and red cells were studied following intravenous infusion. Analyses of concentration curves suggest that they can be resolved into exponential components. Plasma Zn65 becomes protein-bound by 3 hrs following its injection and remains non-dialyzable at least up to 40 days. Red cell Zn65 becomes protein-bound and cannot be removed by dialysis from the hemoglobin solution. Excretion of Zn65 in the urine occurs presumably as an inorganic compound. Fecal excretion of Zn65 is variable and may depend on tissue saturation. The possibility exists that prolonged diarrhea may lead to zinc depletion.
We acknowledge excellent technical assistance of Joseph V. Marino and other members of Laboratory staff.
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