Protection of Mouse Bone Marrow by Inorganic Compounds During Freezing and Thawing

Abstract

Summary

The ability of inorganic compounds to protect mouse bone marrow cells against freezing and thawing damage has been investigated, using a lethally irradiated isologous recipient as a functional assay of viability. NaI, NaBr, NaNO₃, NaNO₂, Na₂SO₄, NaSCN, and Na₂S₂O₃ were tested. All showed protective action against freezing and thawing. The effectiveness of different inorganic salts varied greatly. Each compound was effective only at certain concentrations.