Zn 65 Uptake by Rat Dorsolateral Prostate as Indicator of I.C.S.H. Activity. ∗

Abstract

Summary

Our purpose was to determine which of the following measurements would be the most sensitive indicator of I.C.S.H. activity in hypophysectomized rats, i.e., weight studies of ventral prostate and of DLP, or functional studies of capacity of DLP to concentrate administered Zn⁶⁵ . 0.2 mg of I.C.S.H. daily increased ventral prostate weight and DLP weight 2.3-fold and 2.7-fold, respectively, over hypophysectomized control values. Measurement of functional capacity of DLP to concentrate Zn⁶⁵ was a much more sensitive indicator of I.C.S.H. activity as indicated by the following: 0.2 mg I.C.S.H. increased Zn⁶⁵ uptake/mg DLP 6.7-fold over hypophysectomized control value, and increased total Zn⁶⁵ taken up by the DLP 18.4-fold over hypophysectomized control value.