Abstract
Summary
There is present in inflammatory exudates a diffusible growth-promoting factor which can be purified further from concentrated diffusate by precipitation at pH 4.5 with N acetic acid. Repeated injections of the fraction in its present state of purification induce in non-pregnant rabbits conspicuous hyperplasia of epithelial structures as well as a condition in breast tissue simulating that seen in chronic cystic mastitis. A state of irreversibility is established upon termination of a prolonged course of injections of growth-promoting factor of exudates. The enlarged nipples fail to regress in size, though administration of the active material is discontinued. By enzymatic inactivation, evidence is advanced that both nucleotide and peptide structures appear to play a role in biological activity of the growth-promoting factor of exudates.
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