Cushing's Syndrome V. Chemical Inhibition of 11β-Hydroxylating Enzyme Systems in Hyperplastic and Neoplastic Adrenal Glands. ∗

Abstract

Summary

Administration of Su 4885 resulted in inhibition of 11β-hydroxylation within the adrenal cortex in 7 patients with Cushing's syndrome. In 5 patients with adrenal hyperplasia, this resulted in a rise in values of urinary ketogenic steroids whereas in the 2 patients who had adrenal carcinoma no such rise was observed. This difference in the 2 groups of patients is ascribed to the state of adrenal responsiveness to endogenous ACTH.