Absorption and Tissue Concentrations of Vitamin B 12 in Obese Rats

Abstract

Summary

Rats made obese by feeding high fat diet had more Vit. B₁₂ in the liver and higher plasma Vit. B₁₂ levels than control lean rats receiving same concentration of Vit. B₁₂ in low fat diet. The obese rats absorbed more of orally administered radioactive Vit. B₁₂ than the controls. The increased absorption in obese rats, however, was not directly due to high percentage of fat in the diet and would therefore be accounted for by obesity. The possible involvement of this vitamin in lipid metabolism as based on these findings has been discussed.