Abstract
Summary
1. Carbohydrate feeding reduced chylomicronemia to similarly low levels in normal and nephrotic rats; following such dietary preparation the decreased rate of chylomicron removal from blood of nephrotic rats is not due to dilution of administered chylomicrons. 2. Nephrotic rats were given intravenous injections of 90 mg of normal rat serum albumin. This did not alter rate of removal of labeled chylomicrons from the circulation. 3. When nephrotic rat plasma was added to in vitro clearing system, consisting of normal rat plasma, normal rat chylomicrons and normal rat post-heparin plasma, it significantly decreased rate of clearing. Chylomicrons obtained from normal and nephrotic rats were cleared equally well by serum lipoprotein lipase. 4. Injection of nephrotic rat plasma into normal rats did not alter rate of removal of labeled chylomicrons.
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