Abstract
Summary
1) A method for production of acute pulmonary edema in unanesthetized rabbits and dogs, consisting of slow (60-120 min) intravenous injection of chloroform (0.1 cc/ kg) is presented. 2) Pulmonary edema, as determined by lung-body (L/B) index, occurred in all animals and was accompanied by congestion of liver. 3) Measurements of intracardiac pressures suggest that pulmonary edema is due to relatively greater drop in left than in right ventricular pressure, causing increased pressure in capillaries of lung. 4) Results are believed due to direct depressant effect of chloroform on the myocardium.
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