Abstract
Summary
When dogs with aseptic meningitis were infected with pneumococci intrathecally, a profound drop in CSF glucose occurred which was not observed in control animals given pneumococci without antecedent production of aseptic meningitis, or in animals with aseptic meningitis in absence of superimposed bacterial infection. Hypoglycorrhachia also occurred when heat-killed pneumococci, India ink particles and bacterial endotoxin were administered to animals with aseptic meningitis. These data suggest that the fall in CSF glucose is dependent upon presence of leukocytes engaged in active phagocytosis.
Get full access to this article
View all access options for this article.