Abstract
Summary
The mineralocorticoid effects of 9α-fluorodeoxycorticosterone acetate were investigated in adrenalectomized rats. A quantitative 4-point assay gave potency estimates of 12 and 14.3 for the steroid relative to DCA, as judged by reduction of urinary Na excretion and the ratio of Na K. respectively. Thus, addition of a 9α-fluoro radical can increase mineralocorticoid activity in a steroid lacking oxygen function at carbon 11. These and other published data suggest that 9α-halogenation plays a singularly important part in high DCA-like activity of various 9α-halo corticosteroids.
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