Abstract
Summary
Prolonged oral administration of neomycin resulted in a greater elevation of serum lipids and more severe aortic atherosclerosis and visceral lipoidosis in cholesterolfed rabbits than in untreated cholesterol-fed controls. Failure to observe these enhancing effects following intramuscular administration of neomycin indicates that this action is related to increased absorption of cholesterol. Neomycin was without effect on endogenous cholesterol metabolism in this species.
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