Abstract
Summary
Comparison of effects of 2 aerosols of the same sympathomimetic drug was made. Administration in the usual therapeutic amount of 1 aerosol produced by standard, commercially available, nebulizer caused tachycardia and blood pressure elevation in 4 normal subjects. The other aerosol from a D-30 generator which previously had been shown to relieve bronchoconstriction (5), when breathed in the same manner, failed to have systemic effects. Lack of undesirable side effects from the latter was presumably due to submicroscopic particles emanating from the D-30 generator. They produced a larger surface area to dose ratio and were able to reach areas in the lung where they are locally most effective even though total dose from generator was 30 times less than from the standard nebulizer for a given number of breaths.
Get full access to this article
View all access options for this article.