Abstract
Summary
Patent Blue V, used to visualize lymphatics is excreted in urine in measurable amounts after intradermal injection of 0.1 ml 11% solution. Differences in rates of excretion between edematous and nonedematous subjects suggested that this may be useful in studying rates of uptake of interstitial substances. Control subjects excreted approximately 10% of injected dose in 24 hours. 1/2 of which was excreted in the first 2 1/2 hours. Except for patients who were rapidly losing edema under treatment, rates of excretion were less for subjects with edema of various causes. Correlation of urinary excretion of PBV with that of PSP administered simultaneously but intravenously, and correlation of urinary excretion with rates and areas of local spread of intradermally injected dye, indicate that the principal factor in differences in urinary excretion is decreased uptake and transport by vessels at site of injection.
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