Abstract
Summary and conclusions
The myocardial metabolism of 18 intact dogs was studied during an initial control period and after production of hemorrhagic shock. Some of the dogs were subsequently treated with l-norepinephrine and some with blood. An abnormal myocardial metabolic pattern was demonstrated during shock which was relieved by blood infusion but not by l-norepinephrine. It is suggested that the reason that l-norepinephrine treatment does not increase survival rate of dogs in shock is because it does not correct the basic metabolic abnormality and at the same time imposes a heavier burden of work on the heart.
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