Influence of Local Hypothermia on Absorption from Isolated Intestinal Segments. ∗

Abstract

Conclusions

Our results indicate that hypothermia reduced net transport of substances from gut lumen to blood stream. In strychnine absorption, systemic hypothermia (25-30°C), at clinically feasible levels is not as effective in delaying transport as local hypothermia (10°C). Neither protects the animals from fatal outcome when large doses are used. Hypothermia reduced absorption of RISA approximately ninefold, (p = .005) while it reduced absorption of I¹³¹ only 5-fold (p = <.01). Venous return in hypothermic intestinal loops is reduced 72 and 66% in closed jejunal and ileal segments.