Abstract
Summary
1. Mammary carcinomas occurred in 50% to 100% of 64 F/Fu female rats surviving 90 to 96 days after initiation of intragastric instillation of 3-MCA twice weekly in 10 mg doses, and all of 18 W/Fu rats similarly treated, after 72 days of treatment. In castrated F/Fu male rats similarly treated, no mammary carcinomas developed. 2. Squamous carcinomas arising in periauricular sebaceous glands developed in about one half of both male and female F/Fu rats surviving 123 days, and in none of the W/Fu rats. Similarly, squamous carcinomas of skin and oral mucosa occurred in approximately 12% of F/Fu rats of both sexes and none in W/Fu rats. 3. Leukemias, including lymphoma (about 9%) developed in F/Fu rats and none in W/Fu rats. 4. A single dose of 3-MCA or MtH alone failed to produce mammary carcinomas in 8 W/Fu rats, while 6 of 7 rats receiving both, developed mammary carcinomas.
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