Abstract
Summary
Propagation of Columbia SK virus in Ehrlich ascites cells in vivo is described. After several passages an adapted strain of SK virus having an oncolytic effect was obtained. The adapted strain was relatively non-pathogenic for mice unless accompanied by Ehrlich cells, in which it could propagate freely. This strain, after many passages, maintains ability to agglutinate sheep red cells and is neutralized by antiserum against the original brain virus. The strain shows no cytopathogenicity to Sarcoma 180 cells in tissue culture.
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