Effect of S-(Dichlorovinyl)-L-Cysteine on Incorporation of Precursors into Deoxypentose Nucleic Acid of Leukocytes. ∗

Abstract

Summary

1. When sodium P³²-phosphate was injected intravenously into calves, there was an early labeling of leukocyte DNA. 2. DCVC decreased but did not abolish this uptake of P³² when given concurrently with P³² or when calves were pre-treated with DCVC for 2 or 4 days. 3. When normal calf blood was incubated in presence of H³-thymidine, there was a rapid nuclear uptake by mononuclear leukocytes. 4. DCVC did not inhibit incorporation of H³-thymidine in either blood from DCVC-treated calves or in normal blood incubated in presence of DCVC. 5. Abolishment of DNA synthesis in leukocytes or leukopoietic tissue does not appear to be a primary biochemical lesion through which DCVC induces fatal blood dyscrasia in calves.