Abstract
Summary
(1) Introduction of chondroitin sulfate into the blood stream of rabbits was followed by elevated excretion of acid mucopolysaccharides in urine totalling 5-10% of injected amount over 2-4 days thereafter. Repeated injections were followed by excretions which were still 5-fold greater than baseline levels one week after third and last injection. (2) Repeated subcutaneous injection of disodium EDTA and disodium calcium EDTA into rabbits was followed by a brief and frequently mild rise in urinary excretion of acid mucopolysaccharides; onset, degree and duration of rise varied widely from animal to animal.
The authors are indebted to Harry T. Tully and W. J. K. Rockwell for management of daily urine collections and injection of rabbits and to Sadie Taylor for skillful technical assistance; also to Philip Pickett for preparation and special staining of histologic sections.
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