Abstract
Summary
Daily administration of 2 μg estradiol benzoate plus 6 mg progesterone to mature ovary-thyro-parathyroidectomized rats for 19 days resulted in mammary gland growth (DNA) comparable to ovariectomized rats receiving same treatment. Replacement therapy with 3 μg thyroxine/100 g BW depressed total DFFT and increased DNA concentration but failed to increase total DNA equal to that of ovariectomized rats so treated. These data suggest that higher levels of ovarian hormones may offset thyro-parathyroid hormone deficiencies. With 3 μg thyroxine/100 g BW total DNA of glands did not equal those of ovariectomized group. It is suggested that lack of comparable response may be due either to lack of parathormone or slight excess of thyroxine.
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