Abstract
Summary
Experiments were performed to evaluate quantitatively the effect of Krebs-Ringer medium on contractile capacity of muscle from adrenalectomized albino rats. The triceps brachii was used as test muscle and contraction recorded in situ using the method of Everse and DeFremery. Recovery in contractile capacity subsequent to initial fatiguing of test muscle was expressed as percent of initial contraction height. An overall reduction of 40% in recovery of contractile capacity was observed following adrenalectomy with accompanying hemoconcentration and body weight loss. Following immersion of test muscle in Krebs-Ringer-glucose-phosphate medium for 25 minutes, recovery was restored to levels observed in sham operated controls under similar conditions, but declined to control levels 25 minutes after removal of the nutrient bath. Possible underlying mechanisms are discussed.
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