Abstract
Summary
Normal sera do not inhibit the grossly visible clot formed by addition of hex-amminecobaltic chloride to aqueous solutions of calf thymus DNA. The sera of approximately 66% of patients with DLE inhibit such clot formation. Prior treatment of DNA by active DNase also prevents clot formation, as does addition of histone or protamine to normal sera. The serum factor responsible for such inhibition is removed by prior incubation with whole calf thymus or guinea pig nuclei.
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