Abstract
Summary
Various compounds of metabolic interest, both substrates (citrate, succinate, fumarate, l-malate, pyruvate, dl-lactate, acetate) and an inhibitor (malonate), produced a negative inotropic effect on isolated auricles of the rat. Of the intermediary metabolites the greatest degree of negative inotropic activity was exhibited by citrate and the least by acetate and lactate. Negative inotropic activity of these compounds did not appear to be significantly affected by temperature or addition of glucose to the medium. Results obtained following addition of calcium chloride to the medium, after effects of test compounds were established as well as results from “titration’ experiments, suggest that the effects of metabolites and antimetabolite studied may be related, at least in part, to their capacity to form complexes with calcium.
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