Abstract
Summary
Transamidinase activity in the kidney of rats bearing Walker carcinoma 256 was lower than that of the control. However, concentrations of guanidoacetic acid in plasma and kidney and its excretion in urine of tumor-bearing rats were not changed. In the liver, concentration of this compound was increased with tumor growth. These findings seem to indicate that rate of guanidoacetic acid synthesis is not a limiting factor in synthesis of creatine by the tumor-bearing rat.
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