Experimental Shigella Infections. III. Sensitivity of Normal,Starved and Carbon Tetrachloride Treated Guinea Pigs to Endotoxin

Abstract

Summary

Pretreatment of Hartley strain guinea pigs either by subcutaneous injection with carbon tetrachloride or by 4 day period of starvation renders them more susceptible to intravenously administered endotoxin. The LD₅₀ for normal animals is in excess of 1300 μg; for starved animals 52.8 μg and for carbon tetrachloride treated animals 4.2 μg. Distribution of Cr⁵¹ label of Cr⁵¹ tagged endotoxin in organs of normal animals which survive intravenous dose of 52 μg of endotoxin is the same as that in carbon tetrachloride treated animals which succumb following this challenge.