Abstract
Summary
The adrenocortical response to injected ACTH USP Standard has been studied as a function of time in rats after hypophysectomy or placement of a lesion in median eminence of the hypothalamus. In either case, there is an exponential decrease in sensitivity to ACTH of the adrenal gland, as a function of time. This can be observed in the presence of large adrenal glands, in animals bearing a hypothalamic lesion. The progressive decrease of adrenal sensitivity to ACTH in the lesioned animal makes it desirable to use only an acute preparation as a test for CRF.
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