Factors Affecting Drug Metabolism by Liver Microsomes. IV. Starvation. ∗

Abstract

Summary

Starvation depresses hepatic microsomal drug metabolism both as measured in vitro and in vivo. This depression is believed to be caused by an actual loss of enzyme protein in the microsome. Oxidative pathways are affected more than reductive pathways and indeed starvation may result in an activation of reduction of nitro and azo groups. The nutritional status of the animal prior to drug administration becomes important as a factor in the response obtained. Possible therapeutic implications are discussed.