Plasma Protein VI. Catabolism in vitro. ∗

Abstract

Summary

1. Rat serum albumin randomly labeled with C¹⁴ amino acids was prepared. 2. Neither this serum albumin, nor dialyzed whole plasma similarly labeled, was broken down to any significant extent by any of the tissue slice or homogenate systems tested, although it was anticipated that this should have been demonstrable from breakdown rates calculated from turnover data and from liver perfusion data. 3. It is suggested that either serum albumin breakdown depends on its concentration, the concentration being too low in our experiments; or that albumin is broken down at some other site in the animal.