Abstract
Conclusions
Feeding rats a diet containing 0.3% thiouracil for 3 weeks brought about adrenal atrophy and thyroid and pituitary enlargement as compared to non-thiouracil controls. Pituitary ACTH content of thiouracil rats was less than 1/3 that in controls. The data support the hypothesis that adrenal atrophy following thiouracil is caused by lowered ACTH titers.
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