Abstract
Summary
Lathyrogenic activity of 2-cyanopropylamine (CPA), a methyl analog of BAPN, was studied in chicks, turkey poults and weanling rats. Dissecting aneurisms of the aortae resulted in all 3 species. Although characteristic deformities of leg bones appeared in chicks and turkeys, lathyritic osseous changes were not produced in rats. A toxic symptom produced in all rats by CPA was male priapism. A level of 0.216% CPA in the diet of turkey poults was at least as toxic as 0.079% of BAPN-fumarate. CPA was excreted in urine of rats as unchanged CPA and as 2-cyanopropionic acid.
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