Abstract
Summary
Lysine vasopressin was obtained from commercial pitressin powder by electrophoretic separation. The ACTH releasing activity in the guinea pig and the pressor activity in the cat were compared following various chemical manipulations. Following mild acid and alkaline hydrolysis, iodination, and incubation with placental extract both activities are altered to the same extent. It was concluded that lysine vasopressin causes ACTH release in the guinea pig. This is consistent with the concept that it may be a hypothalamic mediator in this species.
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