B 12 Metabolism and Multiple Sclerosis. ∗

Abstract

Summary

Data have been presented to suggest that MS patients as a group do not metabolize Vit. B₁₂ and GSH, quite in the same quantitative manner as a control group. Their average Vit. B₁₂ serum level is lower, as is their ability to retain the vitamin when administered intramuscularly, although they absorb adequately. Average GSH content of the red blood cell was reduced in the MS group. When Depinar, a Vit. B₁₂−tannate derivative, was administered to such patients, Vit. B₁₂ was excreted much more slowly in urine than aqueous Vit. B₁₂.